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    xol-1 XO lethal protein 1 [ Caenorhabditis elegans ]

    Gene ID: 181061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xol-1
    Official Full Name
    XO lethal protein 1
    Primary source
    WormBase:WBGene00006962
    Locus tag
    CELE_C18A11.5
    See related
    AllianceGenome:WB:WBGene00006962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in dosage compensation by hypoactivation of X chromosome; mRNA alternative trans-splicing; and male sex determination. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xol-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (8041313..8044409)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene tRNA-Pro Neighboring gene SH2 domain-containing protein Neighboring gene Disorganized muscle protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Luz JG, et al. Genes Dev, 2003 Apr 15. PMID 12672694, Free PMC Article
    2. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans. Tang W, et al. Dev Cell, 2018 Mar 26. PMID 29456136, Free PMC Article
    3. Somatic sexual differentiation in Caenorhabditis elegans. Wolff JR, et al. Curr Top Dev Biol, 2008. PMID 19118662
    4. The chromosomal signal for sex determination in Caenorhabditis elegans. Meneely PM. Bioessays, 1997 Nov. PMID 9394616
    5. miRNA-Based Regulation of Alternative RNA Splicing in Metazoans. Schorr AL, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769047, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor tra-1.
      Title: xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.
    2. The XOL-1 protein integrates both X and autosomal signals to determine sexual fate.
      Title: The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dosage compensation by hypoactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA alternative trans-splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in male sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    XO lethal protein 1
    NP_001024418.1
    • Confirmed by transcript evidence
    NP_001024419.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8041313..8044409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029247.3 → NP_001024418.1  XO lethal protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18064, Q23229, Q23230, Q23231, Q7JP92
      Conserved Domains (2) summary
      pfam09108
      Location:18 → 177
      Xol-1_N; Switch protein XOL-1, N-terminal
      pfam09109
      Location:184 → 372
      Xol-1_GHMP-like; Switch protein XOL-1, GHMP-like

    2. NM_001029248.1 → NP_001024419.1  XO lethal protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23229
      Conserved Domains (2) summary
      pfam09108
      Location:18 → 177
      Xol-1_N; Switch protein XOL-1, N-terminal
      pfam09109
      Location:184 → 322
      Xol-1_GHMP-like; Switch protein XOL-1, GHMP-like

    RNA

    1. NR_132547.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23229.1

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