ung-1 Uracil-DNA glycosylase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ung-1
Official Full Name: Uracil-DNA glycosylase
Primary source: WormBase:WBGene00013241
Locus tag: CELE_Y56A3A.29
See related: AllianceGenome:WB:WBGene00013241
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables uracil DNA N-glycosylase activity. Involved in base-excision repair. Located in nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The authors show that ung-1 mutants exhibit a decrease in brood size and lifespan, and an elevated level of germ cell apoptosis when challenged with 5-hydroxymethyluracil.
Title: UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans.
EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans
Title: AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans.
The UNG-1 enzyme is an active uracil-DNA glycosylase involved in repair of DNA damage induced by ionizing radiation.
Title: Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
A cDNA-encoding Caenorhabditis elegans homologue (CeUng-1) of Escherichia coli Ung was cloned and characterized.
Title: Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables uracil DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uracil DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables uracil DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair, AP site formation via deaminated base removal	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info