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    apd-3 AP-3 complex subunit delta;AP-3 complex subunit delta domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173701, updated on 2-Nov-2024

    Summary

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    Official Symbol
    apd-3
    Official Full Name
    AP-3 complex subunit delta;AP-3 complex subunit delta domain-containing protein
    Primary source
    WormBase:WBGene00000162
    Locus tag
    CELE_W09G10.4
    See related
    AllianceGenome:WB:WBGene00000162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in synaptic vesicle membrane organization; synaptic vesicle transport; and vacuolar transport. Predicted to be located in Golgi apparatus and axon cytoplasm. Predicted to be part of AP-3 adaptor complex. Predicted to be active in endosome membrane; presynaptic endosome; and terminal bouton. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See apd-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (3532527..3546431, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene DUF4105 domain-containing protein Neighboring gene DyNactin Complex component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Shim J, et al. Mol Cells, 2005 Jun 30. PMID 15995364
    2. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Kamikura DM, et al. Genes Dev, 2003 Nov 15. PMID 14630941, Free PMC Article
    3. Two Clathrin Adaptor Protein Complexes Instruct Axon-Dendrite Polarity. Li P, et al. Neuron, 2016 May 4. PMID 27151641, Free PMC Article
    4. Adaptins: the final recount. Boehm M, et al. Mol Biol Cell, 2001 Oct. PMID 11598180, Free PMC Article
    5. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Yang S, et al. Neuron, 2022 Mar 2. PMID 35065714, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anterograde synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle budding from endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-3 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit delta;AP-3 complex subunit delta domain-containing protein
    NP_494570.1
    • Confirmed by transcript evidence
    NP_494571.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3532527..3546431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062169.7 → NP_494570.1  AP-3 complex subunit delta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16637
      Conserved Domains (4) summary
      pfam01602
      Location:32 → 581
      Adaptin_N; Adaptin N terminal region
      pfam06375
      Location:692 → 853
      BLVR; Bovine leukaemia virus receptor (BLVR)
      pfam12717
      Location:153 → 265
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:223 → 247
      HEAT; HEAT repeat [structural motif]

    2. NM_062170.5 → NP_494571.1  AP-3 complex subunit delta domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95X88
      Conserved Domains (3) summary
      pfam01602
      Location:1 → 309
      Adaptin_N; Adaptin N terminal region
      pfam06375
      Location:420 → 581
      BLVR; Bovine leukaemia virus receptor (BLVR)
      sd00044
      Location:30 → 60
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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