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    sinh-1 Stress-activated map kinase-interacting protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 190339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sinh-1
    Official Full Name
    Stress-activated map kinase-interacting protein 1 homolog
    Primary source
    WormBase:WBGene00013261
    Locus tag
    CELE_Y57A10A.20
    See related
    AllianceGenome:WB:WBGene00013261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in mesendoderm development. Predicted to be part of TORC2 complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sinh-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (12228305..12238242)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MATH domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene SRRM2 protein homolog rsr-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C. elegans. Longman D, et al. Curr Biol, 2001 Dec 11. PMID 11747818
    2. The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans. Sakai N, et al. PLoS One, 2017. PMID 28542414, Free PMC Article
    3. The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1. Yamashita M, et al. Biochem Biophys Res Commun, 2009 Jan 16. PMID 19028454, Free PMC Article
    4. GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate. Emans SW, et al. Development, 2023 Dec 15. PMID 37982457, Free PMC Article
    5. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Ruf V, et al. Dev Biol, 2013 Dec 15. PMID 23973804, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that a novel molecular interaction between the AEX-1 and syntaxin may regulate vesicle exocytosis for retrograde signal release.
      Title: The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesendoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Stress-activated map kinase-interacting protein 1 homolog
    NP_496596.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12228305..12238242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064195.5 → NP_496596.3  Stress-activated map kinase-interacting protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496596.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NA80
      Conserved Domains (2) summary
      pfam05422
      Location:18 → 117
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:129 → 263
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NA80.3

    Gene LinkOut

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