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    elpc-2 Elongator complex protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176687, updated on 2-Nov-2024

    Summary

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    Official Symbol
    elpc-2
    Official Full Name
    Elongator complex protein 2
    Primary source
    WormBase:WBGene00013738
    Locus tag
    CELE_Y111B2A.17
    See related
    AllianceGenome:WB:WBGene00013738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in tRNA wobble uridine modification. Predicted to be located in cytoplasm and nucleus. Predicted to be part of elongator holoenzyme complex. Is expressed in several structures, including body wall musculature; coelomocyte; excretory cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See elpc-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (12673677..12686225)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine sulfotransferase A Neighboring gene TAFII55 protein conserved region domain-containing protein Neighboring gene putative splicing factor, arginine/serine-rich 3 Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan. Kawamura K, et al. G3 (Bethesda), 2019 Aug 8. PMID 31213517, Free PMC Article
    2. Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans. Fernandes De Abreu DA, et al. Front Cell Dev Biol, 2020. PMID 33195203, Free PMC Article
    3. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Kim S, et al. Genetics, 2010 Aug. PMID 20479142, Free PMC Article
    4. Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in Caenorhabditis elegans. Kawamura K, et al. Aging (Albany NY), 2020 Dec 3. PMID 33276344, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongator complex protein 2
    NP_499648.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12673677..12686225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067247.11 → NP_499648.3  Elongator complex protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499648.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NEW7
      Conserved Domains (3) summary
      COG2319
      Location:46 → 494
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:565 → 606
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:158 → 425
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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