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    fcho-1 FCH domain only protein 2 [ Caenorhabditis elegans ]

    Gene ID: 173511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fcho-1
    Official Full Name
    FCH domain only protein 2
    Primary source
    WormBase:WBGene00018974
    Locus tag
    CELE_F56D12.6
    See related
    AllianceGenome:WB:WBGene00018974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in clathrin-dependent endocytosis. Located in plasma membrane. Is expressed in amphid neurons; hypodermis; intestine; pharyngeal cell; and rectal gland cell. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fcho-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (1310515..1320439)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 2 Neighboring gene ncRNA Neighboring gene Aldehyde dehydrogenase domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hyaluronan/mRNA-binding protein domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Eps15 membrane-binding and -bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis. Wang L, et al. Mol Biol Cell, 2016 Sep 1. PMID 27385343, Free PMC Article
    2. The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. Hollopeter G, et al. Elife, 2014 Oct 10. PMID 25303366, Free PMC Article
    3. Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane. Mayers JR, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818590, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The membrane-associated proteins FCHO1 and SGIP1 are allosteric activators of the AP2 clathrin adaptor complex.
      Title: The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FCH domain only protein 2
    NP_493947.1
    • Confirmed by transcript evidence
    NP_493948.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1310515..1320439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061546.4 → NP_493947.1  FCH domain only protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXS0
      Conserved Domains (2) summary
      cd07648
      Location:14 → 274
      F-BAR_FCHO; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only proteins
      cl10970
      Location:689 → 963
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    2. NM_061547.5 → NP_493948.1  FCH domain only protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYR2
      Conserved Domains (2) summary
      cl10970
      Location:672 → 946
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
      cl12013
      Location:5 → 257
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version

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