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    ral-1 Small monomeric GTPase [ Caenorhabditis elegans ]

    Gene ID: 175433, updated on 2-Nov-2024

    Summary

    Official Symbol
    ral-1
    Official Full Name
    Small monomeric GTPase
    Primary source
    WormBase:WBGene00021811
    Locus tag
    CELE_Y53G8AR.3
    See related
    AllianceGenome:WB:WBGene00021811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including determination of adult lifespan; multivesicular body assembly; and positive regulation of vulval development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including excretory cell; germ line; nervous system; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to several human genes including RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ral-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (3311310..3317716)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene C3H1-type domain-containing protein Neighboring gene PHD-type domain-containing protein

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in multivesicular body assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    Small monomeric GTPase
    NP_001254866.1
    • Confirmed by transcript evidence
    NP_001254867.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3311310..3317716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267937.3NP_001254866.1  Small monomeric GTPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0Q6
      Conserved Domains (2) summary
      cd04139
      Location:59222
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
      smart00173
      Location:59223
      RAS; Ras subfamily of RAS small GTPases
    2. NM_001267938.2NP_001254867.1  Small monomeric GTPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3F8
      Conserved Domains (2) summary
      cd04139
      Location:18181
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
      smart00173
      Location:18182
      RAS; Ras subfamily of RAS small GTPases