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    nhr-41 Nuclear Hormone Receptor family;Nuclear hormone receptor E75;Nuclear receptor [ Caenorhabditis elegans ]

    Gene ID: 190865, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nhr-41
    Official Full Name
    Nuclear Hormone Receptor family;Nuclear hormone receptor E75;Nuclear receptor
    Primary source
    WormBase:WBGene00022423
    Locus tag
    CELE_Y104H12A.1
    See related
    AllianceGenome:WB:WBGene00022423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; hypodermis; intestine; neurons; and vulva. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1) and NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nhr-41 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (1386215..1399353)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene Saposin B-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. Robinson-Rechavi M, et al. J Mol Evol, 2005 May. PMID 15983867
    2. Differential gene expression of Caenorhabditis elegans grown on unmethylated sterols or 4alpha-methylsterols. Merris M, et al. J Lipid Res, 2007 May. PMID 17277379
    3. Genome-wide prediction of C. elegans genetic interactions. Zhong W, et al. Science, 2006 Mar 10. PMID 16527984
    4. Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans. Gissendanner CR, et al. Dev Biol, 2004 Feb 15. PMID 14738886
    5. Nuclear hormone receptors in C. elegans. Antebi A. WormBook, 2006 Jan 3. PMID 18050471, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear Hormone Receptor family;Nuclear hormone receptor E75;Nuclear receptor
    NP_001294480.1
    • Confirmed by transcript evidence
    NP_001294481.1
    • Confirmed by transcript evidence
    NP_001294505.1
    • Partially confirmed by transcript evidence
    NP_001294506.1
    • Confirmed by transcript evidence
    NP_500073.3
    • Product from WormBase gene class nhr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1386215..1399353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067672.6 → NP_500073.3  Nuclear Hormone Receptor family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6V7L1, Q6V7L2, Q6V7L3, Q9N4B8
      UniProtKB/TrEMBL
      G4RWX6, Q3V5L2
      Conserved Domains (3) summary
      cd06967
      Location:147 → 233
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
      smart00818
      Location:6 → 105
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cl11397
      Location:339 → 582
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. NM_001307551.3 → NP_001294480.1  Nuclear hormone receptor E75 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294480.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRQ4
      Conserved Domains (2) summary
      cl02596
      Location:79 → 165
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:271 → 514
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    3. NM_001307552.3 → NP_001294481.1  Nuclear hormone receptor E75 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEU7
      Conserved Domains (2) summary
      cl02596
      Location:45 → 131
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:237 → 480
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    4. NM_001307576.3 → NP_001294505.1  Nuclear hormone receptor E75 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMI0
      Conserved Domains (2) summary
      cl02596
      Location:63 → 149
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:255 → 498
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    5. NM_001307577.3 → NP_001294506.1  Nuclear receptor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294506.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRT9
      Conserved Domains (2) summary
      cl02596
      Location:23 → 109
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:215 → 458
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N4B8.4

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