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    comt-2 Catechol O-methyltransferase domain-containing protein 1 [ Caenorhabditis elegans ]

    Gene ID: 189563, updated on 2-Nov-2024

    Summary

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    Official Symbol
    comt-2
    Official Full Name
    Catechol O-methyltransferase domain-containing protein 1
    Primary source
    WormBase:WBGene00012518
    Locus tag
    CELE_Y32B12A.3
    See related
    AllianceGenome:WB:WBGene00012518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Involved in innate immune response. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See comt-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (16493453..16494489, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Catechol O-methyltransferase domain-containing protein 1
    NP_507175.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16493453..16494489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074774.3 → NP_507175.2  Catechol O-methyltransferase domain-containing protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507175.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXH0
      Conserved Domains (2) summary
      COG4122
      Location:6 → 217
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
      cl17173
      Location:15 → 216
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version

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