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    cgef-1 DH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180571, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cgef-1
    Official Full Name
    DH domain-containing protein
    Primary source
    WormBase:WBGene00006496
    Locus tag
    CELE_C14A11.3
    See related
    AllianceGenome:WB:WBGene00006496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in protein localization. Located in cell cortex and nucleoplasm. Is expressed in hermaphrodite gonad; intestine; neurons; somatic gonad precursor; and vulva. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence); MCF2L (MCF.2 cell line derived transforming sequence like); and MCF2L2 (MCF.2 cell line derived transforming sequence-like 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cgef-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    23
    Sequence:
    Chromosome: X; NC_003284.9 (2772042..2799250)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Death domain-containing protein Neighboring gene DASH complex subunit DAM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans. Li Y, et al. Oncotarget, 2018 Feb 9. PMID 29515755, Free PMC Article
    2. Mechanisms of CDC-42 activation during contact-induced cell polarization. Chan E, et al. J Cell Sci, 2013 Apr 1. PMID 23424200, Free PMC Article
    3. Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans. McMullan R, et al. PLoS Pathog, 2012 Feb. PMID 22359503, Free PMC Article
    4. Regulation of Cdc42 and its effectors in epithelial morphogenesis. Pichaud F, et al. J Cell Sci, 2019 May 21. PMID 31113848
    5. CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo. Kumfer KT, et al. Mol Biol Cell, 2010 Jan 15. PMID 19923324, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DH domain-containing protein
    NP_001123105.1
    • Confirmed by transcript evidence
    NP_741736.2
    • Confirmed by transcript evidence
    NP_741737.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2772042..2799250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171641.6 → NP_741736.2  DH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741736.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYI7
      Conserved Domains (3) summary
      cd00160
      Location:658 → 833
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam13716
      Location:142 → 269
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      cl17171
      Location:841 → 968
      PH-like; Pleckstrin homology-like domain

    2. NM_001129633.5 → NP_001123105.1  DH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYI8
      Conserved Domains (2) summary
      cd00160
      Location:67 → 242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:250 → 377
      PH-like; Pleckstrin homology-like domain

    3. NM_171642.7 → NP_741737.1  DH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02134
      Conserved Domains (2) summary
      cd00160
      Location:67 → 242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:250 → 377
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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