shc-1 SHC-transforming protein homolog 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: shc-1
Official Full Name: SHC-transforming protein homolog 1
Primary source: WormBase:WBGene00018788
Locus tag: CELE_F54A5.3
See related: AllianceGenome:WB:WBGene00018788
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables insulin-like growth factor receptor binding activity; mitogen-activated protein kinase kinase binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of axon regeneration; response to endoplasmic reticulum stress; and response to metal ion. Located in cytoplasm and nucleus. Is expressed in several structures, including anal depressor muscle; hypodermis; intestine; nervous system; and reproductive system. Orthologous to several human genes including SHC4 (SHC adaptor protein 4). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See shc-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (969088..976560, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the scaffold protein SHC-1 interacts with both DDR-2 and SVH-2. Furthermore, we demonstrate that overexpression of svh-2 and shc-1 suppresses the delay in axon regeneration observed in ddr-2 mutants, suggesting that DDR-2 functions upstream of SVH-2 and SHC-1
Title: The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration.
SHC-1 acts as a scaffold to link MAPKKK to MAPKK activation in the KGB-1 MAPK signal transduction pathway.
Title: Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway.
Loss of shc-1 function results in accelerated aging and enhanced sensitivity to heat, oxidative stress, and heavy metals.
Title: SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F54A5.3a (e-PCR)
- UniSTS:320084

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables insulin-like growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metal ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: SHC-transforming protein homolog 1

NP_001379831.1

Confirmed by transcript evidence

NP_490799.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

969088..976560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392658.1 → NP_001379831.1 SHC-transforming protein homolog 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd09925
Location:114 → 222

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cl17171
Location:1 → 61

PH-like; Pleckstrin homology-like domain
NM_058398.6 → NP_490799.2 SHC-transforming protein homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490799.2

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KZG0, H2KZG2, Q9TYT3

Conserved Domains (2) summary

cd09925
Location:203 → 311

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

smart00462
Location:14 → 150

PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain