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    ints-8 INTegrator complex Subunit homolog [ Caenorhabditis elegans ]

    Gene ID: 173216, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints-8
    Official Full Name
    INTegrator complex Subunit homolog
    Primary source
    WormBase:WBGene00013021
    Locus tag
    CELE_Y48G10A.4
    See related
    AllianceGenome:WB:WBGene00013021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS8 (integrator complex subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ints-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (13455356..13470371, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Lysine-specific histone demethylase 1 Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein NDRG3 Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase UBR7;RING-type E3 ubiquitin transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
    2. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    INTegrator complex Subunit homolog
    NP_001252168.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class ints
    NP_001252169.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class ints

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13455356..13470371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265239.4 → NP_001252168.1  INTegrator complex Subunit homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KML7

    2. NM_001265240.3 → NP_001252169.1  INTegrator complex Subunit homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KML6
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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