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    rog-1 IRS-type PTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rog-1
    Official Full Name
    IRS-type PTB domain-containing protein
    Primary source
    WormBase:WBGene00018819
    Locus tag
    CELE_F54D12.6
    See related
    AllianceGenome:WB:WBGene00018819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in germ line. Orthologous to several human genes including FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rog-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (1368102..1374989, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Matsubara Y, et al. Genes Cells, 2007 Mar. PMID 17352744
    2. Caenorhabditis elegans fibroblast growth factor receptor signaling can occur independently of the multi-substrate adaptor FRS2. Lo TW, et al. Genetics, 2010 Jun. PMID 20308281, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IRS-type PTB domain-containing protein
    NP_001263657.1
    • Confirmed by transcript evidence
    NP_493958.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1368102..1374989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276728.3 → NP_001263657.1  IRS-type PTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7LFE2
      Conserved Domains (1) summary
      cd01202
      Location:34 → 124
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    2. NM_061557.3 → NP_493958.2  IRS-type PTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493958.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6N0V1
      Conserved Domains (1) summary
      cd01202
      Location:34 → 124
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    Nucleotide Protein
    Heading Accession and Version

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