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    Y17G9B.5 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 177244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y17G9B.5
    Official Full Name
    Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
    Primary source
    WormBase:WBGene00021202
    Locus tag
    CELE_Y17G9B.5
    See related
    AllianceGenome:WB:WBGene00021202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell surface receptor protein serine/threonine kinase signaling pathway and innate immune response. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y17G9B.5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (4750240..4751491)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cytochrome c 2.1 Neighboring gene Large ribosomal subunit protein eL20 Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
    NP_500631.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4750240..4751491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068230.7 → NP_500631.1  Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N580
      Conserved Domains (3) summary
      sd00004
      Location:82 → 127
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:26 → 211
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:222 → 341
      ECSIT_C; C-terminal domain of the ECSIT protein
    Nucleotide Protein
    Heading Accession and Version

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