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    ints-13 Protein asunder [ Caenorhabditis elegans ]

    Gene ID: 176839, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ints-13
    Official Full Name
    Protein asunder
    Primary source
    WormBase:WBGene00019822
    Locus tag
    CELE_R02D3.4
    See related
    AllianceGenome:WB:WBGene00019822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in centrosome localization and regulation of mitotic cell cycle. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be part of integrator complex. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ints-13 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (232473..237450, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Thioredoxin domain-containing protein Neighboring gene BSD domain-containing protein Neighboring gene Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Neighboring gene Conserved oligomeric Golgi complex subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein asunder
    NP_001368353.1
    • Confirmed by transcript evidence
    NP_001368354.1
    • Confirmed by transcript evidence
    NP_499881.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      232473..237450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067480.5 → NP_499881.1  Protein asunder [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44500
      Conserved Domains (1) summary
      pfam10221
      Location:2 → 744
      DUF2151; Cell cycle and development regulator

    2. NM_001379999.1 → NP_001368353.1  Protein asunder [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PCN0
      Conserved Domains (1) summary
      pfam10221
      Location:1 → 482
      DUF2151; Cell cycle and development regulator

    3. NM_001380000.1 → NP_001368354.1  Protein asunder [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PN35
      Conserved Domains (1) summary
      pfam10221
      Location:8 → 299
      DUF2151; Cell cycle and development regulator
    Nucleotide Protein
    Heading Accession and Version

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