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    otpl-1 OToPetrin-Like;Otopetrin-1;Otopetrin-2 [ Caenorhabditis elegans ]

    Gene ID: 181841, updated on 2-Nov-2024

    Summary

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    Official Symbol
    otpl-1
    Official Full Name
    OToPetrin-Like;Otopetrin-1;Otopetrin-2
    Primary source
    WormBase:WBGene00015035
    Locus tag
    CELE_B0212.1
    See related
    AllianceGenome:WB:WBGene00015035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See otpl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    17
    Sequence:
    Chromosome: IV; NC_003282.8 (3568979..3577770)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene Ion transport domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class E (epsilon) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Enhancer of polycomb homolog 1-like Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Hughes I, et al. BMC Evol Biol, 2008 Feb 6. PMID 18254951, Free PMC Article
    2. An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, et al. Science, 2018 Mar 2. PMID 29371428, Free PMC Article
    3. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, et al. Hum Mol Genet, 2003 Apr 1. PMID 12651873
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables proton channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    OToPetrin-Like;Otopetrin-1;Otopetrin-2
    NP_001294440.1
    • Confirmed by transcript evidence
    NP_001380142.1
    • Product from WormBase gene class otpl;
      Confirmed by transcript evidence
    NP_500374.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3568979..3577770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307511.1 → NP_001294440.1  Otopetrin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEQ1
      Conserved Domains (1) summary
      pfam03189
      Location:304 → 718
      Otopetrin; Otopetrin

    2. NM_001392283.1 → NP_001380142.1  OToPetrin-Like [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBH5
      Conserved Domains (1) summary
      pfam03189
      Location:183 → 597
      Otopetrin

    3. NM_067973.4 → NP_500374.2  Otopetrin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500374.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45067
      Conserved Domains (1) summary
      pfam03189
      Location:167 → 581
      Otopetrin; Otopetrin
    Nucleotide Protein
    Heading Accession and Version

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