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    R05G6.5 Uroporphyrinogen-III synthase [ Caenorhabditis elegans ]

    Gene ID: 187622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R05G6.5
    Official Full Name
    Uroporphyrinogen-III synthase
    Primary source
    WormBase:WBGene00019899
    Locus tag
    CELE_R05G6.5
    See related
    AllianceGenome:WB:WBGene00019899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R05G6.5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (7508367..7509546)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Otopetrin-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative sodium-dependent excitatory amino acid transporter glt-6 Neighboring gene putative voltage-dependent anion-selective channel Neighboring gene Phosphoinositide phospholipase C Neighboring gene ncRNA Neighboring gene Nitric oxide synthase-interacting protein homolog Neighboring gene EGF-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    Uroporphyrinogen-III synthase
    NP_501212.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7508367..7509546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068811.3 → NP_501212.1  Uroporphyrinogen-III synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21753
      Conserved Domains (2) summary
      pfam05186
      Location:147 → 188
      Dpy-30; Dpy-30 motif
      cl00335
      Location:18 → 136
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
    Nucleotide Protein
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