mvb-12 Multivesicular body subunit 12A [Caenorhabditis elegans] - Gene

Summary

Official Symbol: mvb-12
Official Full Name: Multivesicular body subunit 12A
Primary source: WormBase:WBGene00015508
Locus tag: CELE_C06A6.3
See related: AllianceGenome:WB:WBGene00015508
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable SH3 domain binding activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Is expressed in amphid neurons; hypodermis; intestine; and pm7. Orthologous to several human genes including MVB12B (multivesicular body subunit 12B). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport via multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral budding	IBA Inferred from Biological aspect of Ancestor more info
involved_in virus maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT I complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_501302.1

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The following sections contain reference sequences that belong to a specific genome build. Explain