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    R05G6.4 Nitric oxide synthase-interacting protein homolog [ Caenorhabditis elegans ]

    Gene ID: 177526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R05G6.4
    Official Full Name
    Nitric oxide synthase-interacting protein homolog
    Primary source
    WormBase:WBGene00019898
    Locus tag
    CELE_R05G6.4
    See related
    AllianceGenome:WB:WBGene00019898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R05G6.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (7513233..7514407)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen-III synthase Neighboring gene Phosphoinositide phospholipase C Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene Venom peptide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nitric oxide synthase-interacting protein homolog
    NP_501214.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7513233..7514407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068813.10 → NP_501214.1  Nitric oxide synthase-interacting protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21755
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cl17238
      Location:190 → 285
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21755.1

    Gene LinkOut

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