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    nhr-121 Nuclear hormone receptor family member nhr-121 [ Caenorhabditis elegans ]

    Gene ID: 184003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-121
    Official Full Name
    Nuclear hormone receptor family member nhr-121
    Primary source
    WormBase:WBGene00003711
    Locus tag
    CELE_E02H9.8
    See related
    AllianceGenome:WB:WBGene00003711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables steroid hormone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-121 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (2449338..2454807, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Glycoside hydrolase family 1 protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an estrogenic hormone receptor in Caenorhabditis elegans. Mimoto A, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 17963693
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-121
    NP_001122691.1
    • Confirmed by transcript evidence
    NP_497559.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2449338..2454807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129219.6 → NP_001122691.1  Nuclear hormone receptor family member nhr-121 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WJ04
      Conserved Domains (2) summary
      cd06157
      Location:241 → 427
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd06960
      Location:22 → 97
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    2. NM_065158.7 → NP_497559.2  Nuclear hormone receptor family member nhr-121 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497559.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TZ99
      Conserved Domains (2) summary
      cd06157
      Location:241 → 425
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd06960
      Location:22 → 97
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TZ99.2

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