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    neg-1 Negative Effect on Gut development [ Caenorhabditis elegans ]

    Gene ID: 185201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    neg-1
    Official Full Name
    Negative Effect on Gut development
    Primary source
    WormBase:WBGene00017985
    Locus tag
    CELE_F32D1.6
    See related
    AllianceGenome:WB:WBGene00017985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in nucleus. Is expressed in several structures, including AB; AB lineage cell; ABa; Psub1; and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See neg-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (4373754..4374874, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene GMP reductase Neighboring gene Pre-mRNA polyadenylation factor Fip1 domain-containing protein Neighboring gene Protein lilliputian Neighboring gene BSD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetric transcript discovery by RNA-seq in C. elegans blastomeres identifies neg-1, a gene important for anterior morphogenesis. Osborne Nishimura E, et al. PLoS Genet, 2015 Apr. PMID 25875092, Free PMC Article
    2. POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. Elewa A, et al. Dev Cell, 2015 Jul 6. PMID 26096734, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEG-1 localizes in anterior nuclei, where it negatively regulates endo-mesoderm fates
      Title: POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Negative Effect on Gut development
    NP_001256036.1
    • Product from WormBase gene class neg;
      Confirmed by transcript evidence
    NP_001256037.1
    • Product from WormBase gene class neg;
      Confirmed by transcript evidence
    NP_001317810.1
    • Product from WormBase gene class neg;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4373754..4374874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269108.3 → NP_001256037.1  Negative Effect on Gut development [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256037.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16292

    2. NM_001269107.2 → NP_001256036.1  Negative Effect on Gut development [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HA84

    3. NM_001330861.3 → NP_001317810.1  Negative Effect on Gut development [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H505
    Nucleotide Protein
    Heading Accession and Version

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