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    alg-3 Argonaute (plant)-Like Gene [ Caenorhabditis elegans ]

    Gene ID: 178106, updated on 9-Dec-2024

    Summary

    Official Symbol
    alg-3
    Official Full Name
    Argonaute (plant)-Like Gene
    Primary source
    WormBase:WBGene00011910
    Locus tag
    CELE_T22B3.2
    See related
    AllianceGenome:WB:WBGene00011910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in spermatogenesis. Located in P granule. Is expressed in germ line and in male. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
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    Genomic context

    See alg-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (11704246..11708264)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Calcineurin-like phosphoesterase domain-containing protein;Inner membrane protein Neighboring gene Protein dumpy-20 Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Argonaute (plant)-Like Gene
    NP_502217.1
    • Product from WormBase gene class alg;
      Confirmed by transcript evidence
    NP_502218.1
    • Product from WormBase gene class alg;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11704246..11708264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069816.3NP_502217.1  Argonaute (plant)-Like Gene [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED77
      Conserved Domains (5) summary
      PLN03202
      Location:65961
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:369479
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:525960
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:264304
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:87233
      ArgoN; N-terminal domain of argonaute
    2. NM_069817.5NP_502218.1  Argonaute (plant)-Like Gene [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC94
      Conserved Domains (5) summary
      PLN03202
      Location:62958
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:366476
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:522957
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:261301
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:84230
      ArgoN; N-terminal domain of argonaute