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    ints-4 INTegrator complex Subunit homolog [ Caenorhabditis elegans ]

    Gene ID: 173238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints-4
    Official Full Name
    INTegrator complex Subunit homolog
    Primary source
    WormBase:WBGene00012234
    Locus tag
    CELE_W04A4.5
    See related
    AllianceGenome:WB:WBGene00012234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in snRNA processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS4 (integrator complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ints-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (13663352..13674997)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 4 Neighboring gene pseudo Neighboring gene Leucine Rich repeat-containing domain protein Neighboring gene Calpain catalytic domain-containing protein Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
    2. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    INTegrator complex Subunit homolog
    NP_493396.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class ints

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13663352..13674997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060995.9 → NP_493396.1  INTegrator complex Subunit homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493396.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18167
      Conserved Domains (2) summary
      PRK13800
      Location:277 → 552
      PRK13800; fumarate reductase/succinate dehydrogenase flavoprotein subunit
      sd00044
      Location:491 → 518
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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