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    hrde-2 Protein hrde-2 [ Caenorhabditis elegans ]

    Gene ID: 180001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrde-2
    Official Full Name
    Protein hrde-2
    Primary source
    WormBase:WBGene00011324
    Locus tag
    CELE_T01C3.9
    See related
    AllianceGenome:WB:WBGene00011324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in regulatory ncRNA-mediated gene silencing. Predicted to be located in nucleus. Is expressed in Z2; Z3; germ line; sperm; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrde-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (15005100..15006400)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene rRNA 2'-O-methyltransferase fibrillarin Neighboring gene MUTator Neighboring gene Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein Neighboring gene Oxysterol binding protein;Oxysterol-binding protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene SPX domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Family of Argonaute-Interacting Proteins Gates Nuclear RNAi. Lewis A, et al. Mol Cell, 2020 Jun 4. PMID 32348780, Free PMC Article
    2. The RNAi Inheritance Machinery of Caenorhabditis elegans. Spracklin G, et al. Genetics, 2017 Jul. PMID 28533440, Free PMC Article
    3. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Ding YH, et al. Cell Rep, 2023 May 30. PMID 37083324, Free PMC Article
    4. HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1. Chen S, et al. Nat Commun, 2024 Feb 1. PMID 38302462, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1.
      Title: HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein hrde-2
    NP_506693.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15005100..15006400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074292.6 → NP_506693.1  Protein hrde-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22058
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22058.1

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