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    cox-4 Cytochrome c oxidase subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 173237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cox-4
    Official Full Name
    Cytochrome c oxidase subunit 4
    Primary source
    WormBase:WBGene00012354
    Locus tag
    CELE_W09C5.8
    See related
    AllianceGenome:WB:WBGene00012354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cox-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (13658171..13659128, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein eL31 Neighboring gene Inositol phosphatase domain-containing protein;SAC domain-containing protein Neighboring gene pseudo Neighboring gene Leucine Rich repeat-containing domain protein Neighboring gene INTegrator complex Subunit homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dichloroacetate and thiamine improve survival and mitochondrial stress in a C. elegans model of dihydrolipoamide dehydrogenase deficiency. Broxton CN, et al. JCI Insight, 2022 Oct 24. PMID 36278487, Free PMC Article
    2. Complex I function is defective in complex IV-deficient Caenorhabditis elegans. Suthammarak W, et al. J Biol Chem, 2009 Mar 6. PMID 19074434, Free PMC Article
    3. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. Rea SL, et al. PLoS Biol, 2007 Oct 2. PMID 17914900, Free PMC Article
    4. Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Ventura N, et al. Biotechnol J, 2007 May. PMID 17443764
    5. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Samuelson AV, et al. Cold Spring Harb Symp Quant Biol, 2007. PMID 18419309

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome c oxidase subunit 4
    NP_493394.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13658171..13659128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060993.5 → NP_493394.1  Cytochrome c oxidase subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U329
      Conserved Domains (1) summary
      pfam02936
      Location:45 → 175
      COX4; Cytochrome c oxidase subunit IV
    Nucleotide Protein
    Heading Accession and Version

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