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    vab-9 Transmembrane protein 47 [ Caenorhabditis elegans ]

    Gene ID: 188736, updated on 2-Nov-2024

    Summary

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    Official Symbol
    vab-9
    Official Full Name
    Transmembrane protein 47
    Primary source
    WormBase:WBGene00006875
    Locus tag
    CELE_T22C8.8
    See related
    AllianceGenome:WB:WBGene00006875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Is expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to several human genes including TMEM47 (transmembrane protein 47). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See vab-9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8636233..8637715, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Specificity protein transcription factor 2 Neighboring gene Ntox44 domain-containing protein Neighboring gene ZP domain-containing protein Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Integrase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis. Dong Y, et al. Dev Dyn, 2016 Jun. PMID 26990309, Free PMC Article
    2. Claudins reign: The claudin/EMP/PMP22/γ channel protein family in C. elegans. Simske JS. Tissue Barriers, 2013 Jul 1. PMID 24665403, Free PMC Article
    3. The origin of footprints of the Tc1 transposon of Caenorhabditis elegans. Plasterk RH. EMBO J, 1991 Jul. PMID 1646714, Free PMC Article
    4. The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Simske JS, et al. Nat Cell Biol, 2003 Jul. PMID 12819787
    5. The C. elegans zonula occludens ortholog cooperates with the cadherin complex to recruit actin during morphogenesis. Lockwood C, et al. Curr Biol, 2008 Sep 9. PMID 18718757, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 47
    NP_495836.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8636233..8637715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063435.5 → NP_495836.2  Transmembrane protein 47 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495836.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED30
      Conserved Domains (1) summary
      cl21598
      Location:23 → 185
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein
    Heading Accession and Version

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