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    pnc-1 nicotinamidase [ Caenorhabditis elegans ]

    Gene ID: 176833, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pnc-1
    Official Full Name
    nicotinamidase
    Primary source
    WormBase:WBGene00021395
    Locus tag
    CELE_Y38C1AA.3
    See related
    AllianceGenome:WB:WBGene00021395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables nicotinamidase activity. Involved in nicotinamide metabolic process. Located in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including coelomocyte; epithelial cell; ganglia; gland cell; and pharyngeal cell. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pnc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (184484..192151)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene T-cell defective protein 2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene COP9 signalosome complex subunit 3 Neighboring gene GTP cyclohydrolase 1 feedback regulatory protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans. Wang W, et al. J Biol Chem, 2015 Oct 23. PMID 26350462, Free PMC Article
    2. An NAD(+) biosynthetic pathway enzyme functions cell non-autonomously in C. elegans development. Crook M, et al. Dev Dyn, 2014 Aug. PMID 24753121, Free PMC Article
    3. Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans. Vrablik TL, et al. Dev Biol, 2011 Jan 15. PMID 21092737, Free PMC Article
    4. Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans. Vrablik TL, et al. Development, 2009 Nov. PMID 19820182, Free PMC Article
    5. Uridine monophosphate synthetase enables eukaryotic de novo NAD(+) biosynthesis from quinolinic acid. McReynolds MR, et al. J Biol Chem, 2017 Jul 7. PMID 28559281, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nicotinamide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinamidase
    NP_001367799.1
    • Confirmed by transcript evidence
    NP_499876.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      184484..192151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067475.4 → NP_499876.1  nicotinamidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N426
      Conserved Domains (1) summary
      cd01011
      Location:92 → 310
      nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...

    2. NM_001379995.2 → NP_001367799.1  nicotinamidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7WK39
      Conserved Domains (1) summary
      cd01011
      Location:72 → 290
      nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
    Nucleotide Protein
    Heading Accession and Version

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