ubh-3 Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubh-3
Official Full Name: Ubiquitin carboxyl-terminal hydrolase
Primary source: WormBase:WBGene00006723
Locus tag: CELE_Y40G12A.1
See related: AllianceGenome:WB:WBGene00006723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables deNEDDylase activity and deubiquitinase activity. Involved in protein deneddylation. Predicted to be active in cytoplasm. Is expressed in intestinal cell and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; hereditary spastic paraplegia 79A; and hereditary spastic paraplegia 79B. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ubh-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (6506752..6508803, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W01A11.8 (e-PCR)
- UniSTS:322346

F46E10.7 (e-PCR)
- UniSTS:317377

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deNEDDylase activity	IDA Inferred from Direct Assay more info	PubMed
enables deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deneddylation	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ubiquitin carboxyl-terminal hydrolase

NP_504653.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6506752..6508803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072252.8 → NP_504653.2 Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504653.2

Status: REVIEWED

UniProtKB/TrEMBL

Q965V9

Conserved Domains (1) summary

cd09616
Location:9 → 224

Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3