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    nas-39 Zinc metalloproteinase nas-39 [ Caenorhabditis elegans ]

    Gene ID: 3565986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nas-39
    Official Full Name
    Zinc metalloproteinase nas-39
    Primary source
    WormBase:WBGene00003555
    Locus tag
    CELE_F38E9.2
    See related
    AllianceGenome:WB:WBGene00003555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in dorsal/ventral pattern formation and protein processing. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in body wall musculature; intestine; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; coronary artery disease; and osteogenesis imperfecta type 13. Orthologous to several human genes including BMP1 (bone morphogenetic protein 1) and TLL2 (tolloid like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nas-39 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    25
    Sequence:
    Chromosome: X; NC_003284.9 (16456927..16471333)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ADF-H domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene PLCXc domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the astacin family of metalloproteases in C. elegans. Park JO, et al. BMC Dev Biol, 2010 Jan 28. PMID 20109220, Free PMC Article
    2. Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans. Suzuki M, et al. Biol Chem, 2004 Jun. PMID 15255192
    3. A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. Jayadev R, et al. Sci Adv, 2022 May 20. PMID 35584218, Free PMC Article
    4. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc metalloproteinase nas-39
    NP_001360030.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16456927..16471333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373610.4 → NP_001360030.1  Zinc metalloproteinase nas-39 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20176
      Conserved Domains (5) summary
      smart00042
      Location:268 → 343
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      cd00041
      Location:669 → 780
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd04281
      Location:48 → 247
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:519 → 622
      CUB; CUB domain
      pfam14670
      Location:629 → 664
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

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