cit-1.2 Cyclin-T1.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cit-1.2
Official Full Name: Cyclin-T1.2
Primary source: WormBase:WBGene00000508
Locus tag: CELE_F44B9.3
See related: AllianceGenome:WB:WBGene00000508
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cyclin-dependent protein serine/threonine kinase activator activity. Involved in embryo development. Located in nucleus. Is expressed in several structures, including head; intestine; and pharynx. Orthologous to several human genes including CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cit-1.2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (8010772..8013769)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F44B9.3 (e-PCR)
- UniSTS:306231

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Cyclin-T1.2

NP_001370391.1

Partially confirmed by transcript evidence

NP_498745.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8010772..8013769

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382929.1 → NP_001370391.1 Cyclin-T1.2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd20539
Location:1 → 89

CYCLIN_CCNT_rpt2; second cyclin box found in cyclin-T (CCNT) family
NM_066344.6 → NP_498745.1 Cyclin-T1.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498745.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34424, Q8IG20

Conserved Domains (2) summary

COG5333
Location:32 → 321

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

cd00043
Location:50 → 120

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...