tomm-70 Mitochondrial import receptor subunit tomm-70 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tomm-70
Official Full Name: Mitochondrial import receptor subunit tomm-70
Primary source: WormBase:WBGene00022722
Locus tag: CELE_ZK370.8
See related: AllianceGenome:WB:WBGene00022722
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mitochondrion targeting sequence binding activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in several processes, including positive regulation of interferon-beta production; protein targeting to mitochondrion; and regulation of defense response. Located in mitochondrion. Is expressed in muscle cell and tail. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tomm-70 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (8752095..8754750, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chaperone-interacting TPR proteins C33H5.8, C34B2.5 and ZK370.8 may encode weakly conserved homologs of the human proteins RPAP3, TTC1 and TOM70.
Title: Chaperone-interacting TPR proteins in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK370.8 (e-PCR)
- UniSTS:310477

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mitochondrial import receptor subunit tomm-70

NP_498932.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8752095..8754750 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066531.7 → NP_498932.3 Mitochondrial import receptor subunit tomm-70 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498932.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02335

Conserved Domains (2) summary

sd00006
Location:45 → 72

TPR; TPR repeat [structural motif]

pfam13414
Location:45 → 116

TPR_11; TPR repeat