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    zmp-1 Matrix metalloproteinase-A [ Caenorhabditis elegans ]

    Gene ID: 175839, updated on 14-Nov-2024

    Summary

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    Official Symbol
    zmp-1
    Official Full Name
    Matrix metalloproteinase-A
    Primary source
    WormBase:WBGene00006987
    Locus tag
    CELE_EGAP1.3
    See related
    AllianceGenome:WB:WBGene00006987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Is expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Orthologous to human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See zmp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (5926895..5932953, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Tryptophan 2,3-dioxygenase Neighboring gene Uncharacterized protein Neighboring gene putative dynactin subunit 2 Neighboring gene BCL7-like protein Neighboring gene ncRNA Neighboring gene pre-microRNA mir-67 Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene Ubiquitin-related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans. Altincicek B, et al. Dev Comp Immunol, 2010 Nov. PMID 20600277
    2. Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. Naegeli KM, et al. Dev Cell, 2017 Nov 20. PMID 29161591, Free PMC Article
    3. Anchors away! Fos fosters anchor-cell invasion. Montell DJ. Cell, 2005 Jun 17. PMID 15960969
    4. The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis. Kato M, et al. Development, 2009 Dec. PMID 19906858, Free PMC Article
    5. Invadosomes in their natural habitat. Génot E, et al. Eur J Cell Biol, 2014 Oct. PMID 25457677, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in basement membrane disassembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Matrix metalloproteinase-A
    NP_741156.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5926895..5932953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171138.3 → NP_741156.1  Matrix metalloproteinase-A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGM1
      Conserved Domains (3) summary
      cd00094
      Location:308 → 483
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:102 → 257
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam01471
      Location:28 → 75
      PG_binding_1; Putative peptidoglycan binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGM1.1

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