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    lin-46 MoeA N-terminal and linker domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179782, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lin-46
    Official Full Name
    MoeA N-terminal and linker domain-containing protein
    Primary source
    WormBase:WBGene00003031
    Locus tag
    CELE_R186.4
    See related
    AllianceGenome:WB:WBGene00003031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable molecular adaptor activity and molybdopterin molybdotransferase activity. Involved in regulation of development, heterochronic. Located in cytoplasm and nucleus. Is expressed in hypodermis and vulval precursor cell. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lin-46 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (12968855..12970730)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Signal recognition particle receptor subunit beta Neighboring gene 39S ribosomal protein L33, mitochondrial Neighboring gene Pinin/SDK/MemA protein domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans. Ilbay O, et al. Development, 2019 Nov 6. PMID 31597658, Free PMC Article
    2. C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA. Ilbay O, et al. Cell Rep, 2021 Sep 7. PMID 34496246, Free PMC Article
    3. Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects. Li M, et al. Dev Cell, 2005 Sep. PMID 16139229
    4. Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42. Tennessen JM, et al. Dev Biol, 2006 Jan 1. PMID 16300753
    5. Heterochronic genes and the temporal control of C. elegans development. Ambros V, et al. Trends Genet, 1994 Apr. PMID 8029828

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. robust progression from L2 to L3 cell fates depends on the combination of two distinct modes of HBL-1 downregulation: decreased synthesis of HBL-1 via let-7-family microRNA activity, and decreased nuclear accumulation of HBL-1 via action of the lin-28-lin-46 pathway
      Title: Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans.
    2. Data suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development.
      Title: The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables molybdopterin adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin molybdotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdopterin molybdotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of synaptic specificity at neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MoeA N-terminal and linker domain-containing protein
    NP_506246.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12968855..12970730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073845.5 → NP_506246.1  MoeA N-terminal and linker domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF06
      Conserved Domains (1) summary
      cd00887
      Location:27 → 387
      MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
    Nucleotide Protein
    Heading Accession and Version

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