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    csk-1 Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1 [ Caenorhabditis elegans ]

    Gene ID: 266817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csk-1
    Official Full Name
    Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1
    Primary source
    WormBase:WBGene00000812
    Locus tag
    CELE_Y48G1C.2
    See related
    AllianceGenome:WB:WBGene00000812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein tyrosine kinase activity. Involved in several processes, including larval feeding behavior; nematode larval development; and nematode pharyngeal pumping. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including anus; head neurons; hermaphrodite somatic gonadal cell; pharyngeal muscle cell; and vulval cell. Orthologous to several human genes including CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See csk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (71425..81061)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Myotubularin phosphatase domain-containing protein Neighboring gene HTH CENPB-type domain-containing protein Neighboring gene Sm domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans. Takata N, et al. Genes Cells, 2009 Mar. PMID 19210548
    2. Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans. Hirose T, et al. FEBS Lett, 2003 Jan 16. PMID 12527374
    3. Caenorhabditis elegans fibroblast growth factor receptor signaling can occur independently of the multi-substrate adaptor FRS2. Lo TW, et al. Genetics, 2010 Jun. PMID 20308281, Free PMC Article
    4. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Shirayama M, et al. Curr Biol, 2006 Jan 10. PMID 16343905
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that CSK-1 has an essential function in organization of pharyngeal muscle filaments that does not require C. elegans Src family tyrosine kinases.
      Title: Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.
    2. results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1
      Title: Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein;Tyrosine-protein kinase csk-1
    NP_001293162.1
    • Partially confirmed by transcript evidence
    NP_001293163.1
    • Confirmed by transcript evidence
    NP_001379977.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      71425..81061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306233.3 → NP_001293162.1  Tyrosine-protein kinase csk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECJ6
      Conserved Domains (2) summary
      cd09937
      Location:232 → 330
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd05039
      Location:362 → 620
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    2. NM_001392355.1 → NP_001379977.1  Tyrosine-protein kinase csk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECJ6, V6CL92
      Conserved Domains (2) summary
      cd09937
      Location:147 → 245
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cd05039
      Location:277 → 535
      PTKc_Csk_like; Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases

    3. NM_001306234.3 → NP_001293163.1  Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CL68
      Conserved Domains (1) summary
      cl21453
      Location:1 → 39
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECJ6.1

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