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    ZK688.5 Ubiquitin-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZK688.5
    Official Full Name
    Ubiquitin-like domain-containing protein
    Primary source
    WormBase:WBGene00022800
    Locus tag
    CELE_ZK688.5
    See related
    AllianceGenome:WB:WBGene00022800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable misfolded protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ERAD pathway. Predicted to be part of BAT3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZK688.5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (7885084..7891623, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TIP41-like protein Neighboring gene Transmembrane protein Neighboring gene Oxaloacetate tautomerase fahd-1, mitochondrial Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like domain-containing protein
    NP_001366828.1
    • Confirmed by transcript evidence
    NP_001367397.1
    • Confirmed by transcript evidence
    NP_001367398.1
    • Confirmed by transcript evidence
    NP_001368171.1
    • Confirmed by transcript evidence
    NP_001370894.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7885084..7891623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379806.2 → NP_001366828.1  Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34675, Q8I7F0
      UniProtKB/TrEMBL
      A0A679L8U9
      Conserved Domains (1) summary
      smart00213
      Location:21 → 92
      UBQ; Ubiquitin homologues

    2. NM_001379808.1 → NP_001368171.1  Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34675, Q8I7F0
      UniProtKB/TrEMBL
      L8EC34
      Conserved Domains (1) summary
      smart00213
      Location:21 → 92
      UBQ; Ubiquitin homologues

    3. NM_001382922.1 → NP_001370894.1  Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E805
      Conserved Domains (1) summary
      smart00213
      Location:21 → 92
      UBQ; Ubiquitin homologues

    4. NM_001379805.3 → NP_001367397.1  Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34675, Q8I7F0
      Conserved Domains (1) summary
      smart00213
      Location:21 → 92
      UBQ; Ubiquitin homologues

    5. NM_001379807.1 → NP_001367398.1  Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34675, Q8I7F0
      Conserved Domains (1) summary
      smart00213
      Location:21 → 92
      UBQ; Ubiquitin homologues
    Nucleotide Protein
    Heading Accession and Version

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