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    pap-1 Poly(A) polymerase [ Caenorhabditis elegans ]

    Gene ID: 179458, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pap-1
    Official Full Name
    Poly(A) polymerase
    Primary source
    WormBase:WBGene00012528
    Locus tag
    CELE_Y32F6A.3
    See related
    AllianceGenome:WB:WBGene00012528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and mRNA processing. Predicted to be active in nucleus. Is expressed in body wall musculature; intestine; and nervous system. Orthologous to several human genes including PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pap-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10441981..10446467)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SET domain-containing protein Neighboring gene Transporter Neighboring gene Retinoid-inducible serine carboxypeptidase Neighboring gene pseudo Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Wang L, et al. Nature, 2002 Sep 19. PMID 12239571
    2. Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans. Van Epps H, et al. Development, 2010 Jul. PMID 20530551, Free PMC Article
    3. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans. Vieux KF, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34586415, Free PMC Article
    4. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Poly(A) polymerase
    NP_001379022.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10441981..10446467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392595.1 → NP_001379022.1  Poly(A) polymerase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2P3
      Conserved Domains (2) summary
      pfam04926
      Location:362 → 461
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:13 → 360
      PAP_central; Poly(A) polymerase central domain
    Nucleotide Protein
    Heading Accession and Version

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