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    lam-1 Laminin subunit beta-1 [ Caenorhabditis elegans ]

    Gene ID: 177292, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lam-1
    Official Full Name
    Laminin subunit beta-1
    Primary source
    WormBase:WBGene00002247
    Locus tag
    CELE_W03F8.5
    See related
    AllianceGenome:WB:WBGene00002247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in pharynx development and positive regulation of locomotion. Located in basement membrane. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Pierson syndrome; amelogenesis imperfecta type 1A; autistic disorder; lissencephaly 5; and nephrotic syndrome type 5. Orthologous to several human genes including LAMB1 (laminin subunit beta 1) and LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lam-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (5173332..5183746)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EKC/KEOPS complex subunit TPRKB Neighboring gene Activin_recp domain-containing protein;DUF3309 domain-containing protein;Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans. Kao G, et al. Dev Biol, 2006 Feb 1. PMID 16376872
    2. Laminin is required to orient epithelial polarity in the C. elegans pharynx. Rasmussen JP, et al. Development, 2012 Jun. PMID 22535412, Free PMC Article
    3. Membrane extensions are associated with proper anterior migration of muscle cells during Caenorhabditis elegans embryogenesis. Viveiros R, et al. Dev Biol, 2011 Oct 1. PMID 21820426
    4. Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model. Jafari G, et al. Genetics, 2010 Nov. PMID 20805556, Free PMC Article
    5. Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Levitan D, et al. Development, 1998 Sep. PMID 9716525

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Laminin subunit beta-1
    NP_001368376.1
    • Confirmed by transcript evidence
    NP_500734.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5173332..5183746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068333.6 → NP_500734.3  Laminin subunit beta-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500734.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44565
      Conserved Domains (6) summary
      smart00136
      Location:31 → 273
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:779 → 824
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:1088 → 1144
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:827 → 876
      Laminin_EGF; Laminin EGF domain
      cl12013
      Location:1197 → 1327
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19854
      Location:1448 → 1565
      DUF1002; Protein of unknown function (DUF1002)

    2. NM_001380214.1 → NP_001368376.1  Laminin subunit beta-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIX7
      Conserved Domains (1) summary
      cl40438
      Location:8 → 75
      cc_LAMB_C; C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family
    Nucleotide Protein
    Heading Accession and Version

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