smk-1 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smk-1
Official Full Name: Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein
Primary source: WormBase:WBGene00018285
Locus tag: CELE_F41E6.4
See related: AllianceGenome:WB:WBGene00018285
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein phosphatase activator activity. Involved in several processes, including defense response to bacterium; negative regulation of mitotic DNA damage checkpoint; and response to X-ray. Located in nucleus. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and pharynx. Orthologous to several human genes including PPP4R3A (protein phosphatase 4 regulatory subunit 3A) and PPP4R3B (protein phosphatase 4 regulatory subunit 3B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smk-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (8607800..8615843)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans.
Title: DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans.
Results report a new component of the insulin/IGF-1 signaling longevity pathway, SMK-1, which specifically influences DAF-16-dependent regulation of the aging process in C. elegans by regulating the transcriptional specificity of DAF-16 activity.
Title: SMK-1, an essential regulator of DAF-16-mediated longevity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F41E6.4 (e-PCR)
- UniSTS:319332

F41E6.10 (e-PCR)
- UniSTS:320971

F41E6.3 (e-PCR)
- UniSTS:312319

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic DNA damage checkpoint	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitotic DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase 4 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein

NP_001023909.2

Partially confirmed by transcript evidence

NP_001023910.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8607800..8615843

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028738.8 → NP_001023909.2 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023909.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KYN6

Conserved Domains (1) summary

pfam04802
Location:341 → 534

SMK-1; Component of IIS longevity pathway SMK-1
NM_001028739.6 → NP_001023910.2 Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023910.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KYN7

Conserved Domains (1) summary

pfam04802
Location:105 → 298

SMK-1; Component of IIS longevity pathway SMK-1