sys-1 Beta-catenin homolog sys-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sys-1
Official Full Name: Beta-catenin homolog sys-1
Primary source: WormBase:WBGene00006379
Locus tag: CELE_T23D8.9
See related: AllianceGenome:WB:WBGene00006379
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; scaffold protein binding activity; and transcription coactivator activity. Involved in several processes, including cell fate commitment involved in formation of primary germ layer; gonad development; and regulation of gene expression. Located in several cellular components, including cell cortex; kinetochore; and pericentriolar material. Is expressed in several structures, including ABplpapaap; ABprpapaap; P7.pa; posterior distal tip cell; and tail hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sys-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (9980063..9984794, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results indicate that SYS-1 and POP-1 levels are influenced by the parent cell's SYS-1/POP-1 levels and this may provide an additional mechanism by which POP-1 regulates distinct targets in different developmental contexts.
Title: Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans.
Data show that centrosomal targeting of SYS-1 promotes its degradation during asymmetric cell division.
Title: Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division.
SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1
Title: Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity in C. elegans.
Animals with reduced function of the beta-catenins SYS-1 and WRM-1 have as few as 3 seam cells. The 'Wnt/beta-catenin asymmetry' pathway is required for the proper stem cell-like asymmetric division of seam cells.
Title: Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development.
Either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis.
Title: The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway.
SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
Title: The C. elegans SYS-1 protein is a bona fide beta-catenin.
There are two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates.
Title: Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1.
binds the POP-1/TCF beta-catenin binding domain, and coactivates POP-1-dependent transcription
Title: A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling.
SYS-1 causes all SGP daughters to adopt the proximal fate.
Title: Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad.
Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans.
Title: Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23D8.4 (e-PCR)
- UniSTS:308085

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of proximal/distal axis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polarity specification of proximal/distal axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Beta-catenin homolog sys-1

NP_001300438.1

Confirmed by transcript evidence

NP_001379282.1

Confirmed by transcript evidence

NP_492639.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9980063..9984794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060238.6 → NP_492639.1 Beta-catenin homolog sys-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3ARA0, Q95ZN3, Q9XVI2
NM_001392922.1 → NP_001379282.1 Beta-catenin homolog sys-1 [Caenorhabditis elegans]

Status: REVIEWED
NM_001313509.3 → NP_001300438.1 Beta-catenin homolog sys-1 [Caenorhabditis elegans]

Status: REVIEWED