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    rnf-145 RING finger protein 145 homolog [ Caenorhabditis elegans ]

    Gene ID: 172053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rnf-145
    Official Full Name
    RING finger protein 145 homolog
    Primary source
    WormBase:WBGene00022471
    Locus tag
    CELE_Y119C1B.5
    See related
    AllianceGenome:WB:WBGene00022471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cis-Golgi network and trans-Golgi network. Is expressed in several structures, including body wall musculature; intestine; nervous system; non-striated muscle; and pharynx. Orthologous to human RNF145 (ring finger protein 145). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rnf-145 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (4511438..4516089, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Receptor-type guanylate cyclase gcy-28 Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein bL19m Neighboring gene Neuropeptide-Like Protein Neighboring gene Conserved plasma membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism. Zhang A, et al. PLoS Biol, 2020 Dec. PMID 33370778, Free PMC Article
    2. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING finger protein 145 homolog
    NP_491382.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4511438..4516089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058981.7 → NP_491382.2  RING finger protein 145 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491382.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Y82
      Conserved Domains (2) summary
      cd16476
      Location:590 → 631
      RING-H2_RNF139_like; RING finger, H2 subclass, found in RING finger proteins RNF139, RNF145, and similar proteins
      pfam13705
      Location:49 → 556
      TRC8_N; TRC8 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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