hcp-6 Condensin-2 complex subunit hcp-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hcp-6
Official Full Name: Condensin-2 complex subunit hcp-6
Primary source: WormBase:WBGene00001833
Locus tag: CELE_Y110A7A.1
See related: AllianceGenome:WB:WBGene00001833
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone binding activity. Involved in attachment of mitotic spindle microtubules to kinetochore; embryo development; and mitotic chromosome condensation. Located in condensed chromosome, centromeric region and nucleoplasm. Part of condensin complex. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD3 (non-SMC condensin II complex subunit D3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hcp-6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (5165148..5171313)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The loss of the condensin II protein HCP-6 or MIX-1/SMC2 impaired centromere resolution
Title: HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IEA Inferred from Electronic Annotation more info
part_of condensin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Condensin-2 complex subunit hcp-6

NP_491537.1

Confirmed by transcript evidence

NP_491538.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5165148..5171313

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059136.4 → NP_491537.1 Condensin-2 complex subunit hcp-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491537.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95Y84, Q9N583

Conserved Domains (2) summary

sd00044
Location:1041 → 1070

HEAT; HEAT repeat [structural motif]

pfam12717
Location:1057 → 1153

Cnd1; non-SMC mitotic condensation complex subunit 1
NM_059137.6 → NP_491538.1 Condensin-2 complex subunit hcp-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491538.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N583

Conserved Domains (2) summary

sd00044
Location:1041 → 1070

HEAT; HEAT repeat [structural motif]

pfam12717
Location:1057 → 1153

Cnd1; non-SMC mitotic condensation complex subunit 1