rpl-4 Large ribosomal subunit protein uL4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpl-4
Official Full Name: Large ribosomal subunit protein uL4
Primary source: WormBase:WBGene00004415
Locus tag: CELE_B0041.4
See related: AllianceGenome:WB:WBGene00004415
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in determination of adult lifespan. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpl-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (4645662..4646963, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPL-4 and RPL-9 Mediated Ribosome Purifications Facilitate the Efficient Analysis of Gene Expression in Caenorhabditis elegans Germ Cells.
Title: RPL-4 and RPL-9 ̶Mediated Ribosome Purifications Facilitate the Efficient Analysis of Gene Expression in Caenorhabditis elegans Germ Cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0041.4 (e-PCR)
- UniSTS:308822

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Large ribosomal subunit protein uL4

NP_491416.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4645662..4646963 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059015.8 → NP_491416.1 Large ribosomal subunit protein uL4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491416.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02056

Conserved Domains (3) summary

PTZ00428
Location:1 → 345

PTZ00428; 60S ribosomal protein L4; Provisional

pfam14374
Location:275 → 345

Ribos_L4_asso_C; 60S ribosomal protein L4 C-terminal domain

cl00325
Location:7 → 264

Ribosomal_L4; Ribosomal protein L4/L1 family