nfya-1 Nuclear transcription factor Y subunit nfya-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nfya-1
Official Full Name: Nuclear transcription factor Y subunit nfya-1
Primary source: WormBase:WBGene00011614
Locus tag: CELE_T08D10.1
See related: AllianceGenome:WB:WBGene00011614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription repressor activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of nematode male tail tip morphogenesis; and tissue development. Located in nucleus. Is expressed in several structures, including IL1 neuron; excretory cell; head neurons; oocyte; and somatic nervous system. Used to study cancer. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nfya-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (11944285..11946838, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nfya-1 functions as a substrate of ERK-MAP kinase during Caenorhabditis elegans vulval development.
Title: Nfya-1 functions as a substrate of ERK-MAP kinase during Caenorhabditis elegans vulval development.
These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Title: The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin.
Title: NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T08D10.1 (e-PCR)
- UniSTS:311627

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear transcription factor Y subunit nfya-1

NP_509999.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11944285..11946838 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077598.5 → NP_509999.1 Nuclear transcription factor Y subunit nfya-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509999.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEG1

Conserved Domains (2) summary

smart00521
Location:300 → 361

CBF; CCAAT-Binding transcription Factor

PHA03247
Location:4 → 84

PHA03247; large tegument protein UL36; Provisional