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    uaf-2 RNA-binding protein;Splicing factor U2AF 35 kDa subunit [ Caenorhabditis elegans ]

    Gene ID: 178489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uaf-2
    Official Full Name
    RNA-binding protein;Splicing factor U2AF 35 kDa subunit
    Primary source
    WormBase:WBGene00006698
    Locus tag
    CELE_Y116A8C.35
    See related
    AllianceGenome:WB:WBGene00006698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables pre-mRNA 3'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2AF complex. Is expressed in several structures, including anal depressor muscle; excretory cell; nervous system; rectal epithelium; and reproductive system. Orthologous to human U2AF1 (U2 small nuclear RNA auxiliary factor 1) and U2AF1L4 (U2 small nuclear RNA auxiliary factor 1 like 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uaf-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (17116771..17118552, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Branchpoint-bridging protein Neighboring gene WSN domain-containing protein;protein of unknown function WSN domain-containing protein Neighboring gene Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Intersectin-1;SH3 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Both subunits of U2AF recognize the 3' splice site in Caenorhabditis elegans. Zorio DA, et al. Nature, 1999 Dec 16. PMID 10617207
    2. U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans. Zorio DA, et al. RNA, 1999 Apr. PMID 10199565, Free PMC Article
    3. In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans. Ma L, et al. RNA, 2011 Dec. PMID 22033331, Free PMC Article
    4. Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability. Mazroui R, et al. RNA, 1999 Dec. PMID 10606272, Free PMC Article
    5. Translational suppression via IFG-1/eIF4G inhibits stress-induced RNA alternative splicing in Caenorhabditis elegans. Chomyshen SC, et al. Genetics, 2022 Jul 4. PMID 35536193, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA 3'-splice site binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2AF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein;Splicing factor U2AF 35 kDa subunit
    NP_001299977.1
    • Confirmed by transcript evidence
    NP_503036.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17116771..17118552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070635.6 → NP_503036.1  Splicing factor U2AF 35 kDa subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2U0
      Conserved Domains (2) summary
      cd12538
      Location:51 → 155
      RRM_U2AF35; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)
      pfam00642
      Location:21 → 45
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    2. NM_001313048.3 → NP_001299977.1  RNA-binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXF6
    Nucleotide Protein
    Heading Accession and Version

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