dpy-22 Mediator of RNA polymerase II transcription subunit 12 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpy-22
Official Full Name: Mediator of RNA polymerase II transcription subunit 12
Primary source: WormBase:WBGene00001081
Locus tag: CELE_F47A4.2
See related: AllianceGenome:WB:WBGene00001081
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transcription coactivator activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of vulval development. Located in nucleus. Is expressed in several structures, including intestine; rectum; and vulva. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to several human genes including MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dpy-22 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (9810202..9822273, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LET-19 and DPY-22 in the Mediator complex repress the transcription of Wnt target genes and are required for asymmetric cell division.
Title: Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-167 (e-PCR)
- UniSTS:242548

F47A4.2 (e-PCR)
- UniSTS:321484

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mediator of RNA polymerase II transcription subunit 12

NP_509645.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9810202..9822273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077244.4 → NP_509645.1 Mediator of RNA polymerase II transcription subunit 12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509645.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20497

Conserved Domains (8) summary

PHA00671
Location:2690 → 2760

PHA00671; hypothetical protein

pfam05672
Location:2623 → 2729

MAP7; MAP7 (E-MAP-115) family

pfam09497
Location:99 → 158

Med12; Transcription mediator complex subunit Med12

pfam12145
Location:815 → 990

Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

pfam15346
Location:2523 → 2662

ARGLU; Arginine and glutamate-rich 1

cd16269
Location:2710 → 2721

GBP_C; coiled coil [structural motif]

cl20817
Location:2630 → 2728

GBP_C; Guanylate-binding protein, C-terminal domain

cl23782
Location:2728 → 2784

RCR; Chitin synthesis regulation, resistance to Congo red