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    rin-1 Protein kinase domain-containing protein;Protein sprint;Rab-GAP TBC domain-containing protein;SH2 domain-containing protein;TLDc domain-containing protein;VPS9 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rin-1
    Official Full Name
    Protein kinase domain-containing protein;Protein sprint;Rab-GAP TBC domain-containing protein;SH2 domain-containing protein;TLDc domain-containing protein;VPS9 domain-containing protein
    Primary source
    WormBase:WBGene00008183
    Locus tag
    CELE_C48G7.3
    See related
    AllianceGenome:WB:WBGene00008183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase binding activity. Involved in dorsal/ventral axon guidance and neuron migration. Located in cell periphery; cytoplasm; and filopodium. Is expressed in body wall musculature; gonad; head neurons; and hypodermis. Orthologous to several human genes including RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rin-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    26
    Sequence:
    Chromosome: V; NC_003283.11 (14784151..14815600, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Integrin_alpha2 domain-containing protein Neighboring gene THAP-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans. Doi M, et al. Development, 2013 Aug. PMID 23900541, Free PMC Article
    2. A model to die for: signaling to apoptotic cell removal in worm, fly and mouse. Kinchen JM. Apoptosis, 2010 Sep. PMID 20461556
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in rin-1 cause axon guidance defects in some types of neuron. [rin1; C48G7.3]
      Title: The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal/ventral axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;Protein sprint;Rab-GAP TBC domain-containing protein;SH2 domain-containing protein;TLDc domain-containing protein;VPS9 domain-containing protein
    NP_001122880.1
    • Confirmed by transcript evidence
    NP_001122883.1
    • Confirmed by transcript evidence
    NP_001256619.1
    • Confirmed by transcript evidence
    NP_001256620.1
    • Confirmed by transcript evidence
    NP_001256621.1
    • Confirmed by transcript evidence
    NP_001256622.1
    • Confirmed by transcript evidence
    NP_001256623.1
    • Confirmed by transcript evidence
    NP_001263893.1
    • Confirmed by transcript evidence
    NP_001263894.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14784151..14815600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129408.5 → NP_001122880.1  SH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MVE8, G5ECF0
      Conserved Domains (3) summary
      cd01776
      Location:1791 → 1879
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:1624 → 1738
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:376 → 489
      SH2; Src homology 2 (SH2) domain

    2. NM_001269693.4 → NP_001256622.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBS9
      Conserved Domains (2) summary
      cd01776
      Location:835 → 923
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:668 → 782
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    3. NM_001269690.3 → NP_001256619.1  Protein sprint [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MVE8, G5EDQ3
      Conserved Domains (3) summary
      cd01776
      Location:1646 → 1734
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl15255
      Location:231 → 344
      SH2; Src homology 2 (SH2) domain
      cl19569
      Location:1479 → 1593
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    4. NM_001269691.3 → NP_001256620.1  Protein sprint [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MVE8, G5EG71
      Conserved Domains (3) summary
      cd01776
      Location:1541 → 1629
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl15255
      Location:126 → 239
      SH2; Src homology 2 (SH2) domain
      cl19569
      Location:1374 → 1488
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    5. NM_001269692.3 → NP_001256621.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFI0
      Conserved Domains (2) summary
      cd01776
      Location:1269 → 1357
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:1102 → 1216
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    6. NM_001276964.3 → NP_001263893.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7LFF0
      Conserved Domains (2) summary
      cd01776
      Location:921 → 1009
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:754 → 868
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    7. NM_001276965.3 → NP_001263894.1  TLDc domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7J4D1
      Conserved Domains (2) summary
      cd01776
      Location:848 → 936
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:681 → 795
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    8. NM_001129411.4 → NP_001122883.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED02
      Conserved Domains (2) summary
      cd01776
      Location:818 → 906
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:651 → 765
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    9. NM_001269694.3 → NP_001256623.1  VPS9 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFE4
      Conserved Domains (2) summary
      cd01776
      Location:563 → 651
      RA_Rin; Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family
      cl19569
      Location:396 → 510
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    Nucleotide Protein
    Heading Accession and Version

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