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    nex-1 Annexin [ Caenorhabditis elegans ]

    Gene ID: 175714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nex-1
    Official Full Name
    Annexin
    Primary source
    WormBase:WBGene00003588
    Locus tag
    CELE_ZC155.1
    See related
    AllianceGenome:WB:WBGene00003588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heparin binding activity and phospholipid binding activity. Involved in engulfment of apoptotic cell. Located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in hypodermis; pharynx; spermathecal-uterine junction; uterine toroidal epithelial cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nex-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (5225621..5226804)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cuticlin-like protein 19 Neighboring gene Histone H2A/H2B/H3 domain-containing protein Neighboring gene rRNA-processing protein UTP23 homolog Neighboring gene CHCH domain-containing protein;CX9C domain-containing protein Neighboring gene ATP synthase subunit beta, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ligand-binding properties of annexin from Caenorhabditis elegans (annexin XVI, Nex-1). Satoh A, et al. J Biochem, 2000 Sep. PMID 10965035
    2. Caenorhabditis elegans proteins captured by immobilized Galβ1-4Fuc disaccharide units: assignment of 3 annexins. Takeuchi T, et al. Carbohydr Res, 2011 Sep 27. PMID 21798523
    3. Identification, localization, and functional implications of an abundant nematode annexin. Creutz CE, et al. J Cell Biol, 1996 Mar. PMID 8601586, Free PMC Article
    4. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
    5. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Annexin
    NP_498109.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5225621..5226804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065708.10 → NP_498109.1  Annexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEA8
      Conserved Domains (3) summary
      smart00335
      Location:33 → 81
      ANX; Annexin repeats
      pfam00191
      Location:88 → 153
      Annexin; Annexin
      cl02574
      Location:192 → 238
      Annexin; Annexin
    Nucleotide Protein
    Heading Accession and Version

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