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    T24H7.2 Hypoxia up-regulated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 174033, updated on 2-Nov-2024

    Summary

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    Official Symbol
    T24H7.2
    Official Full Name
    Hypoxia up-regulated protein 1
    Primary source
    WormBase:WBGene00020781
    Locus tag
    CELE_T24H7.2
    See related
    AllianceGenome:WB:WBGene00020781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be part of endoplasmic reticulum chaperone complex. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See T24H7.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (6247311..6250844)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 4 Neighboring gene GSKIP domain-containing protein Neighboring gene ncRNA Neighboring gene Mitochondrial prohibitin complex protein 2 Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Lipase_GDSL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hypoxia up-regulated protein 1
    NP_495249.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6247311..6250844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062848.6 → NP_495249.1  Hypoxia up-regulated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495249.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22758
      Conserved Domains (2) summary
      cd10230
      Location:27 → 413
      HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
      COG0443
      Location:29 → 669
      DnaK; Molecular chaperone DnaK (HSP70) [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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