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    unc-44 AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177366, updated on 2-Nov-2024

    Summary

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    Official Symbol
    unc-44
    Official Full Name
    AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein
    Primary source
    WormBase:WBGene00006780
    Locus tag
    CELE_B0350.2
    See related
    AllianceGenome:WB:WBGene00006780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cell adhesion molecule binding activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and netrin-activated signaling pathway. Located in lateral plasma membrane. Is expressed in several structures, including hermaphrodite gonad; hypodermis; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); ankyrin-B-related cardiac arrhythmia; autosomal recessive intellectual developmental disorder 37; bipolar disorder; and heart conduction disease (multiple). Orthologous to several human genes including ANK2 (ankyrin 2) and ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See unc-44 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    20
    Sequence:
    Chromosome: IV; NC_003282.8 (5975557..6004857)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of the Caenorhabditis elegans ankyrin gene unc-44 demonstrates that the large spliceoform is critical for neural development. Boontrakulpoontawee P, et al. Mol Genet Genomics, 2002 May. PMID 12073031
    2. An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans. Otsuka AJ, et al. J Cell Biol, 1995 May. PMID 7744957, Free PMC Article
    3. A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. Aguirre-Chen C, et al. G3 (Bethesda), 2020 May 4. PMID 32132169, Free PMC Article
    4. UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting. Maniar TA, et al. Nat Neurosci, 2011 Nov 20. PMID 22101643, Free PMC Article
    5. unc-44 Ankyrin and stn-2 gamma-syntrophin regulate sax-7 L1CAM function in maintaining neuronal positioning in Caenorhabditis elegans. Zhou S, et al. Genetics, 2008 Nov. PMID 18791240, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics
      Title: Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
    2. We suggest that UNC-44 and UNC-33 direct polarized sorting through their global effects on neuronal microtubule organization.
      Title: UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemorepulsion of axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in netrin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dorsal/ventral axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein
    NP_001021266.2
    • Partially confirmed by transcript evidence
    NP_001021267.1
    • Confirmed by transcript evidence
    NP_001367343.1
    • Confirmed by transcript evidence
    NP_001367344.1
    • Confirmed by transcript evidence
    NP_001367345.1
    • Confirmed by transcript evidence
    NP_001368407.1
    • Confirmed by transcript evidence
    NP_001368408.1
    • Confirmed by transcript evidence
    NP_001368409.1
    • Confirmed by transcript evidence
    NP_500901.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5975557..6004857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380250.2 → NP_001367343.1  Ankyrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECZ1
      Conserved Domains (8) summary
      smart00218
      Location:1000 → 1104
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242 → 648
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:37 → 387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:1497 → 1574
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424 → 455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756 → 807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1331 → 1466
      UPA_2; UPA domain
      cl39094
      Location:555 → 780
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001380251.2 → NP_001367344.1  AO66 ankyrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQG0
      Conserved Domains (8) summary
      smart00218
      Location:1000 → 1104
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242 → 648
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:37 → 387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:1497 → 1574
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424 → 455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756 → 807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1331 → 1466
      UPA_2; UPA domain
      cl39094
      Location:555 → 780
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001380252.2 → NP_001368407.1  Ankyrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP86
      Conserved Domains (8) summary
      smart00218
      Location:1008 → 1110
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242 → 648
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:37 → 387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:1503 → 1580
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424 → 455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756 → 807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1337 → 1472
      UPA_2; UPA domain
      cl39094
      Location:555 → 780
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001380249.1 → NP_001367345.1  AO66 ankyrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17343, Q17490
      Conserved Domains (9) summary
      smart00218
      Location:1008 → 1110
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242 → 648
      PHA02876; ankyrin repeat protein; Provisional
      PTZ00449
      Location:1770 → 2112
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:37 → 387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:1503 → 1580
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424 → 455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756 → 807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:1337 → 1472
      UPA_2; UPA domain
      cl39094
      Location:555 → 780
      Ank_2; Ankyrin repeats (3 copies)

    5. NM_001380253.1 → NP_001368408.1  UNC-44 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17341, V6CLS7
      Conserved Domains (3) summary
      smart00218
      Location:167 → 271
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:664 → 741
      Death_ank; Death domain associated with Ankyrins
      pfam17809
      Location:498 → 633
      UPA_2; UPA domain

    6. NM_001380254.1 → NP_001368409.1  UNC-44 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17341, V6CLR6
      Conserved Domains (3) summary
      smart00218
      Location:175 → 277
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:670 → 747
      Death_ank; Death domain associated with Ankyrins
      pfam17809
      Location:504 → 639
      UPA_2; UPA domain

    7. NM_068500.5 → NP_500901.2  ZU5 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500901.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17341, Q5TYL6
      Conserved Domains (2) summary
      smart00218
      Location:96 → 200
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:593 → 670
      Death_ank; Death domain associated with Ankyrins

    8. NM_001026096.4 → NP_001021267.1  ZU5 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17342, Q5TYL5
      Conserved Domains (2) summary
      smart00218
      Location:1 → 90
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:483 → 560
      Death_ank; Death domain associated with Ankyrins

    9. NM_001026095.6 → NP_001021266.2  Trans-sialidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17489
    Nucleotide Protein
    Heading Accession and Version

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