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    emc-1 ER membrane protein complex subunit 1;WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    emc-1
    Official Full Name
    ER membrane protein complex subunit 1;WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00019209
    Locus tag
    CELE_H17B01.4
    See related
    AllianceGenome:WB:WBGene00019209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Human ortholog(s) of this gene implicated in cerebellar atrophy, visual impairment, and psychomotor retardation. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See emc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (1489930..1500330, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene pseudo Neighboring gene Facilitated glucose transporter protein 1 Neighboring gene ncRNA Neighboring gene MATH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 1;WD_REPEATS_REGION domain-containing protein
    NP_493980.1
    • Confirmed by transcript evidence
    NP_872011.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1489930..1500330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061579.7 → NP_493980.1  ER membrane protein complex subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493980.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0C0
      Conserved Domains (2) summary
      COG2319
      Location:74 → 317
      WD40; WD40 repeat [General function prediction only]
      pfam07774
      Location:737 → 945
      DUF1620; Protein of unknown function (DUF1620)

    2. NM_182211.5 → NP_872011.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S39
      Conserved Domains (1) summary
      COG2319
      Location:74 → 317
      WD40; WD40 repeat [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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